Displaying 55 (all) recruiting clinical trials.
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A Phase I Study of ExoFlo an ex vivo Culture-expanded Adult Allogeneic Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicle Isolate Product for the Treatment of Medically Refractory Ulcerative Colitis
Patients with Ulcerative Colitis are often managed with corticosteroids, immunomodulators and monoclonal antibodies, all fraught with potential side effects. The advent of the biologic era ...Phase
Interventional
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A Phase 1 Multicenter Open-Label Study Of CC-97540 (BMS-986353) CD19-Targeted Nex-T Chimeric Antigen Receptor (CAR) T Cells in Participants with Severe Refractory Autoimmune Diseases: Systemic Lupus Erythematosus Idiopathic Inflammatory Myopathy or Systemic Sclerosis
SLE disease activity results in accumulation of tissue and organ damage (eg, nephritis, multisystem organ failure, and central nervous disease) that contributes to morbidity and ...Phase
Interventional
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PRostate Cancer Treatment with the AQUABEAM Robotic System
Prospective, multicenter, single-arm clinical trial, designed to evaluate the safety of the AQUABEAM Robotic System in treating patients with localized prostate cancer.Phase
Interventional
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A Phase Ib/II Open-Label Multicenter Study Evaluating the Safety Activity And Pharmacokinetics of Divarasib in Combination with Other Anti-Cancer Therapies in Patients with Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer with a KRAS G12C Mutation
A Phase Ib/II, Open-Label, Multicenter Study Evaluating the Safety, Activity, And Pharmacokinetics of Divarasib in Combination with Other Anti-Cancer Therapies in Patients with Previously ...Phase
Interventional
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Phase 1 First-in-Human Dose Escalation and Expansion Study to Assess Safety and Tolerability of Intravenous Administration of ICVB-1042 in Patients with Advanced Solid Tumors
Although recent advances have been made in the treatment of some solid tumors, there remains a high unmet need for patients who have malignancies that ...Phase
Interventional
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A phase I open-label multi-center study of KFA115 as a single agent and in combination with pembrolizumab in patients with select advanced cancers
This study is a FIH, open-label, phase I, multi-center study that consists of two treatment arms in dose escalation: single-agent KFA115 (Arm A escalation) and ...Phase
Interventional
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The HistoSonics Edison System for treatment of primary solid renal tumors using histotripsy (#HOPE4KIDNEY US)
This trial is a prospective, multi-center, single-arm pivotal trial designed to evaluate the effectiveness and safety of the HistoSonics Edison System for the destruction of ...Phase
Interventional
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A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Safety Tolerability Pharmacokinetics of AHB-137 with Single Ascending Doses and Multiple Doses in Healthy Volunteers and Initial Efficacy in Chronic Hepatitis B Patients
This phase I study is designed to evaluate the safety, tolerability, and pharmacokinetics of AHB-137 in healthy participants and initial efficacy in CHB patients. A ...Phase
Interventional
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Development and Piloting of a Family-Centered mHealth-Enhanced Intervention to Promote Caregiving Mastery in Detection Prevention and Management of Delirium Superimposed on Dementia
Delirium superimposed on dementia (DSD) is an acute and serious condition that is common in persons living with dementia (PLWD). Involvement of family caregivers can ...Phase
Interventional
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A Multicenter Open-Label Study of RMC-6236 in Patients with Advanced Solid Tumors Harboring Specific Mutations in RAS
A Multicenter Open-Label Study of RMC-6236 in Patients with Advanced Solid Tumors Harboring Specific Mutations in RASPhase
Interventional
