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A sham-controlled pilot trial of focused ultrasound modulation of the globus pallidus interna in schizophrenia
The primary objectives of this study are to examine the tolerability of pulsed low-intensity focused ultrasound (PLIFUS) and its effects on brain function measured via ...Phase
Interventional
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A green activity prescription program for Chinese Americans living with dementia
This study will iteratively develop and test the feasibility and acceptability of a 12-week green prescription program among Chinese American people living with dementia and ...Phase
Interventional
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Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression R33
~60 subjects with MDD will undergo MRI scanning during t-PBM (administered with an irradiance of 291.7 mW/cm2 for 333s) before and after a ...Phase
Interventional
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A Phase 2b Double-Blind Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
This study includes a . screening period . 12-week double-blind, placebo-controlled treatment period . 48-week double-blind treatment period, and . post-treatment follow-up. At Week 12, participants receiving placebo Q4W ...Phase
Interventional
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Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP II)
A Phase II study to assess the safety and efficacy of AVB-114 in treatment of complex Crohn’s perianal fistulas in subjects with quiescent rectal ...Phase
Interventional
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A multi-cohort randomized Phase 2 open-label study to assess the preliminary efficacy safety and pharmacokinetics of BIVV020 for prevention and treatment of antibody-mediated rejection in adult kidney transplant recipients.
Antibody-mediated rejection (AMR) remains as the most common cause of allograft failure following kidney transplantation (1, 2). The primary mechanism of AMR involves activation of ...Phase
Interventional
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A Single-Arm Phase 2 Study Of Daratumumab In Previously Treated Stk11/Lkb1 Mutated Non-Small Cell Lung Cancer
This is a single arm, signal finding study of daratumumab in metastatic NSCLC patients with an STK11/LKB1 mutation. Patients will have received previous standard ...Phase
Interventional
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Safety and Efficacy of the Alleviant System for No-Implant Interatrial Shunt Creation in Patients with Chronic Heart Failure (ALLAY-HF)
ALLAY-HF is a prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using ...Phase
Interventional
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I-SPY 2 TRIAL -Investigation of Serial Studies to Predict your Therapeutic Response with Imaging and Molecular Analysis 2
The I-SPY 2.2 protocol uses the same strategy as the I-SPY 2.0 protocol to optimize response, measuring the impact of each therapeutic regimen ...Phase
Interventional
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A Phase II Multicenter Double-Blind Randomised Placebo-Controlled Study and Open-Label Long Term Extension to Evaluate the Safety and Efficacy of Elafibranor in Adult Participants with Primary Sclerosing Cholangitis (PSC)
The sponsor is conducting this phase II study to evaluate the safety and tolerability of 2 doses of elafibranor in participants with PSC, and its ...Phase
Interventional
