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A Pilot Phase II Open-Label Single-Center Study of Sodium-Glucose Cotransporter-2 Inhibitor Empagliflozin in Major Depressive Disorder
This is an open-label, single arm clinical trial preliminarily testing the antidepressant effects of empagliflozin in patients with major depressive disorder (MDD), and assessing its ...Phase
Interventional
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A sham-controlled pilot trial of focused ultrasound modulation of the globus pallidus interna in schizophrenia
The primary objectives of this study are to examine the tolerability of pulsed low-intensity focused ultrasound (PLIFUS) and its effects on brain function measured via ...Phase
Interventional
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A green activity prescription program for Chinese Americans living with dementia
This study will iteratively develop and test the feasibility and acceptability of a 12-week green prescription program among Chinese American people living with dementia and ...Phase
Interventional
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Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression R33
~60 subjects with MDD will undergo MRI scanning during t-PBM (administered with an irradiance of 291.7 mW/cm2 for 333s) before and after a ...Phase
Interventional
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A Phase 2b Double-Blind Placebo-Controlled Study to Evaluate Peresolimab in Adult Participants with Moderately-to-Severely Active Rheumatoid Arthritis
This study includes a . screening period . 12-week double-blind, placebo-controlled treatment period . 48-week double-blind treatment period, and . post-treatment follow-up. At Week 12, participants receiving placebo Q4W ...Phase
Interventional
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Seeded Cells on Matrix Plug Treating Crohn's Perianal Fistulas (STOMP II)
A Phase II study to assess the safety and efficacy of AVB-114 in treatment of complex Crohn’s perianal fistulas in subjects with quiescent rectal ...Phase
Interventional
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A multi-cohort randomized Phase 2 open-label study to assess the preliminary efficacy safety and pharmacokinetics of BIVV020 for prevention and treatment of antibody-mediated rejection in adult kidney transplant recipients.
Antibody-mediated rejection (AMR) remains as the most common cause of allograft failure following kidney transplantation (1, 2). The primary mechanism of AMR involves activation of ...Phase
Interventional
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A Single-Arm Phase 2 Study Of Daratumumab In Previously Treated Stk11/Lkb1 Mutated Non-Small Cell Lung Cancer
This is a single arm, signal finding study of daratumumab in metastatic NSCLC patients with an STK11/LKB1 mutation. Patients will have received previous standard ...Phase
Interventional
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Safety and Efficacy of the Alleviant System for No-Implant Interatrial Shunt Creation in Patients with Chronic Heart Failure (ALLAY-HF)
ALLAY-HF is a prospective, multicenter, randomized, sham-controlled, double blinded, adaptive study designed to evaluate the safety and efficacy of a percutaneously created interatrial shunt using ...Phase
Interventional
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I-SPY 2 TRIAL -Investigation of Serial Studies to Predict your Therapeutic Response with Imaging and Molecular Analysis 2
The I-SPY 2.2 protocol uses the same strategy as the I-SPY 2.0 protocol to optimize response, measuring the impact of each therapeutic regimen ...Phase
Interventional
