Displaying 83 (all) recruiting clinical trials.
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A Phase 2 study to investigate efficacy safety tolerability and pharmacokinetics of JZP3507 (ONC206) in adults with recurrent Grade 2 or 3 Meningioma
This is a Phase 2 study testing a new drug called JZP3507 (an investigational anti-cancer drug) in patients with Grade 2 or Grade 3 meningioma ...
Phase
Interventional
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A Multicenter Randomized Vehicle-Controlled Double-Masked to Open-Label Study to Evaluate the Safety and Efficacy of Lacripep 4 M (0.001 % w/v) Ophthalmic Solution in Subjects with Neurotrophic Keratitis
The purpose of this study is to find out whether an eye drop called Lacripep is safe and whether it can help people with Stage ...Phase
Interventional
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Randomized Phase 2 Trial of Ruxolitinib in Combination with Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma
This is a Phase 2 study testing a new treatment approach for newly diagnosed glioblastoma. It compares ruxolitinib plus radiation and temozolomide to the standard ...
Phase
Interventional
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A Phase 2 Open-label Study of VS-7375 an Oral KRAS G12D (ON/OFF) Inhibitor as Monotherapy and with Cetuximab in Patients with Metastatic KRAS G12D-Mutated Pancreatic Cancer (TARGET-D 201)
This is a Phase 2, open-label study for adults with metastatic pancreatic cancer that has a KRAS G12D gene mutation. The study is testing an ...
Phase
Interventional
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A Phase 2b Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Tulisokibart in Participants With Psoriatic Arthritis
The purpose of this study is to evaluate the efficacy, safety, and tolerability of tulisokibart in participants with active psoriatic arthritis (PsA) when compared to ...Phase
Interventional
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A PHASE II PROSPECTIVE TRIAL UTILIZING SHORT COURSE ANDROGEN DEPRIVATION THERAPY IN CONJUNCTION WITH ULTRA-HYPOFRACTIONATED SBRT FOR HIGH RISK NCCN PROSTATE CANCER WITH LOWER RISK ARTERA SCORES
This is a Phase 2 study for patients with high-risk prostate cancer who have Gleason scores of 8–10 or PSA levels between 20 and ...
Phase
Interventional
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A Multi-center Phase 2 Study of Hippocampal Avoidance in Craniospinal Irradiation for Leptomeningeal Metastases from Solid Tumors
This is a Phase 2 clinical study done at multiple hospitals that is testing a special type of radiation treatment called craniospinal irradiation (CSI) with ...
Phase
Interventional
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A PHASE II SINGLE-ARM SINGLE-CENTER STUDY EVALUATING TOXICITY OUTCOMES AND DOSIMETRY USING AN MR-GUIDED LINEAR ACCELERATOR FOR THE TREATMENT OF EARLY STAGE KIDNEY CANCER
This Phase II single arm study will prospectively enroll 30 patients. Patients have a simulation visit, where treatment planning includes an MRI scan to check ...Phase
Interventional
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A Study of GS-3242 in Combination with Lenacapavir Versus Bictegravir/Emtricitabine/Tenofovir Alafenamide in Virologically Suppressed People with HIV-1
The purpose of this clinical trial is to evaluate the safety and effectiveness of an investigational long-acting injectable HIV treatment regimen for people living with ...Phase
Interventional
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RLY-2608-201: A Phase 2 Study of Mutant-selective PI3Ka Inhibitor RLY-2608 in Adults and Children with PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation
The purpose of this study is to learn about the safety and efficacy of RLY-2608 when given to individuals who have been diagnosed with PIK3CA ...Phase
Interventional
