Displaying 99 (all) recruiting clinical trials.
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A Phase 2 Open-Label Study to Evaluate the Safety and Efficacy of DCR-PHXC in Patients With Primary Hyperoxaluria Type 1 or 2 and Severe Renal Impairment With or Without Dialysis
The purpose of this study is to learn whether the study drug DCR-PHXC is safe and able to treat patients with Primary Hyperoxaluria Type 1 ...Phase
Interventional
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A Phase IIa Open-label Clinical Trial to Evaluate the Safety Pharmacokinetics Pharmacodynamics and Efficacy of BP1001 (a Liposomal Grb2 Antisense Oligonucleotide) in Combination with Venetoclax plus Decitabine in Patients with Acute Myeloid Leukemia (AML) Who Are Ineligible for Intensive Induction Therapy
The first purpose of this study is to learn if combining the study drug BP1001 with the standard-of-care drugs Venetoclax and decitabine in first line ...Phase
Interventional
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A Phase 2 Basket Study of Tucatinib in Combination With Trastuzumab in Subjects With Previously Treated Locally Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations
The purpose of the study is to determine how well tucatinib works with trastuzumab for solid tumors that make either more HER2 or a different ...Phase
Interventional
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Multicenter Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy Safety and Tolerability of 36 weeks of treatment with NLY01 in Early-Stage Parkinson s Disease
Parkinson’s disease is a condition that interferes with body movement. The condition usually worsens over time. Research suggests that inflammation in certain areas of ...Phase
Interventional
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Safety and Efficacy of AMG 570 in Subjects With Active Systemic Lupus Erythematosus (SLE)
This study is being done to learn more about AMG 570 in people with systemic lupus erythematosus (SLE). The purpose of the study is to ...Phase
Interventional
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Flexible Surface Coil for MRI
The purpose of this study is to test if we can use a redesigned device of the Magnetic Resonance Imaging (MRI) scanner, called a coil ...Phase
Interventional
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A PHASE II OPEN-LABEL MULTICENTER STUDY EVALUATING THE SAFETY AND EFFICACY OF NEOADJUVANT AND ADJUVANT TIRAGOLUMAB PLUS ATEZOLIZUMAB WITH OR WITHOUT PLATINUM-BASED CHEMOTHERAPY IN PATIENTS WITH PREVIOUSLY UNTREATED LOCALLY ADVANCED RESECTABLE STAGE II IIIA OR SELECT IIIB NON-SMALL CELL LUNG CANCER
The purpose of the study is to determine the surgical safety and feasibility of atezolizumab plus tiragolumab alone (Atezo and Tira) or in combination with ...Phase
Interventional
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An Umbrella Study of INCMGA00012 Alone and in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-Based Chemotherapy (POD1UM-204)
The purpose of the study is to determine the safety and efficacy of INCMGA00012 monotherapy or in combination with other immunotherapy or targeted agents (combinations ...Phase
Interventional
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APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1 BRCA2 or PALB2 Mutation
This phase II trial investigates how well the addition of olaparib following completion of surgery and chemotherapy works in treating patients with pancreatic cancer that ...Phase
Interventional
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GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients
The purpose of the trial is to assess the safety and efficacy of the Gene Mediated Cytotoxic Immunotherapy (GMCI) added to standard of care immune ...Phase
Interventional
