Displaying 79 (all) recruiting clinical trials.
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A Phase 2 Study of Blinatumomab in Combination with Chemotherapy for Infants with Newly Diagnosed Acute Lymphoblastic Leukemia with Randomization of KMT2A-Rearranged Patients to Addition of Venetoclax
This phase II trial tests the addition of venetoclax and/or blinatumomab to usual chemotherapy for treating infants with newly diagnosed acute lymphoblastic leukemia (ALL ...Phase
Interventional
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A Phase II randomized open-label multi-center study of JSB462 (luxdegalutamide) in combination with abiraterone in adult male patients with metastatic hormone-sensitive prostate cancer (mHSPC)
This Phase II study aims to evaluate efficacy and safety of the combination of JSB462 (also known as luxdegalutamide) at 100 mg and 300 mg ...Phase
Interventional
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A Phase II Trial Evaluating Chemotherapy followed by Response-Based Reduced Radiation Therapy for Patients with Central Nervous System Germinomas
This is a phase II study, testing if lowering the dose of standard radiotherapy (RT) after standard chemotherapy medicines (Carboplatin & Etoposide) works well with fewer ...
Phase
Interventional
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Novel Targeting of the Microenvironment to Decrease Metastatic Recurrence of High-Risk TNBC: A Randomized Phase II Study of Tetrathiomolybdate (TM) Plus Capecitabine in Patients with Breast Cancer at High Risk of Recurrence
Scientific Rationale for the study design: Copper depletion is designed to be a complement to standard therapy to overcome resistance mechanisms hence it would be ...Phase
Interventional
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Comparison of High Dose vs. Standard Dose Influenza Vaccines in Lung Allograft Recipients
The purpose of this study is to investigate if receiving two doses of Fluzone High-Dose is better than receiving two doses of the standard dose ...Phase
Interventional
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A Phase 2 Double-blind Placebo-Controlled Study to Evaluate LY3537021 for the Treatment of Chemotherapy-Induced Nausea and Vomiting in Adult Participants With Malignant Disease
This is a Phase 2 study testing how safe and effective a medicine called LY3537021 is when added to standard anti-nausea treatment. LY3537021 is a ...
Phase
Interventional
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A Global Phase 2b Randomized Double-Blinded Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients with Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy FORTITUDE-HCM
The purpose of this study is to examine the effects of ninerafaxstat (an investigational drug) in people who are experiencing symptoms from their Non-Obstructive Hypertrophic ...Phase
Interventional
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An Open-label Multi-center Global Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX43 (Anti-PD-L1 ADC) in Subjects with Advanced Non-small Cell Lung Cancer (NSCLC)
HLX43 is a fully human monoclonal antibody drug conjugate targeting PD-L1, which is prepared by conjugating an antibody specifically targeting PD-L1 to a toxin-peptide chain ...Phase
Interventional
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A Phase 2 Randomized Double-blind Placebo-controlled Parallel Study Evaluating the Safety and Efficacy of LB-P8 in Patients with Primary Sclerosing Cholangitis (PSC)
This main purpose of this placebo-controlled study to assess the safety and efficacy of LB-P8 in adult patients with Primary Sclerosing Cholangitis (PSC). The study ...Phase
Interventional
