Displaying 74 (all) recruiting clinical trials.
-
A Phase II multicenter open-label trial of tagraxofusp (Tag) in combination with venetoclax and azacitidine (Ven/Aza) in adults with previously untreated CD123+ acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy
This study looks at how safe and effective a medicine called Tag is when combined with Ven and Aza for people with CD123+ acute myeloid ...
Phase
Interventional
-
A Multi-center Randomized Open-label Parallel-group Phase 2 Study to Evaluate the Efficacy and Safety of VS-101 in Combination with Chemoradiotherapy (CRT) in Patients with Head and Neck Cancer
This is a Phase 2 study testing the study medicine VS-101 (an oral radiosensitizer) in combination with Chemoradiotherapy (CRT) in patients with head and neck ...
Phase
Interventional
-
PNOC022: A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas (DMGs) including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis Post-Radiation Therapy and at Time of Progression
This research is for kids and young adults who have a specific kind of brain tumor called DMG (Diffuse Midline Gliomas). We're testing different ...
Phase
Interventional
-
Phase II Trial of SMO/ AKT/ NF2/CDK Inhibitors in Progressive Meningiomas with SMO/ AKT/ NF2/CDK Pathway Mutations
This is a phase 2 study testing how well the study medicines vismodegib (a Hedgehog pathway inhibitor), GSK2256098 (a selective focal adhesion kinase (FAK) inhibitor ...
Phase
Interventional
-
GS-US-457-6411: A Phase 2 Double-Blinded Randomized Placebo-Controlled Dose-Ranging Study Evaluating the Efficacy and Safety of GS-5290 in Participants with Moderately to Severely Active Ulcerative Colitis
The goal of this study is to learn if investigational drug tilpisertib fosmecarbil (formerly known as GS-5290) is effective and safe in treating participants with ...Phase
Interventional
-
A Phase 2 Randomized Double-Blind Placebo-Controlled Multicenter Dose Ranging Study Evaluating the Efficacy and Safety of GS-1427 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)
The study team is evaluating an oral investigational drug to see if it reduces the signs and symptoms of moderately to severely active ulcerative colitis ...Phase
Interventional
-
A Phase 2a Multicenter Randomized Double-Blind Placebo- Controlled Study of the Safety and Efficacy of TB006 in Participants with Parkinson s Disease
The purpose of this study is to see if the study drug improves motor function in Parkinson's disease (PD) patients.Phase
Interventional
-
PNOC029: Nivolumab and DAY101 for the treatment of newly diagnosed or recurrent craniopharyngioma in children and young adults
This study is designed for patients who have craniopharyngioma (a rare brain tumor). The usual treatment for craniopharyngioma involves surgery and radiation, which helps reduce ...
Phase
Interventional
-
A multi-center randomized (1:1) controlled phase 2 trial of STIMULAN VG with debridement and a course of systemic antibiotics vs standard of care (SoC) for the treatment of osteomyelitis associated with stage IV pressure ulcers.
This study is being performed to find out if the use of a new investigational product (meaning not approved by the Food and Drug Administration ...Phase
Interventional
-
AALL1821: A Phase 2 Study of Blinatumomab (NSC# 765986 IND# 125462) in Combination with Nivolumab (NSC# 748726 IND# 125462) a Checkpoint Inhibitor of PD-1 in B-ALL Patients Aged >/=1 to
The purpose of the study is to study the effect of nivolumab in combination with blinatumomab compared to blinatumomab alone in treating patients with B-cell ...
Phase
Interventional
