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A Two Part Phase IIa/b Multicentre Randomised Double-Blind Placebo-Controlled Parallel Group Dose-ranging Study to Assess Efficacy Safety and Tolerability of the Combination of Zibotentan and Dapagliflozin and Dapagliflozin Monotherapy Versus Placebo in Participants with Cirrhosis with Features of Portal Hypertension
The main purpose of this study is to learn more about the effects of two drugs called zibotentan and dapagliflozin, in patients with liver disease ...Phase
Interventional
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Effectiveness and impact of counseling enhanced with electronic cigarettes for harm reduction in smokers with opioid use disorder
We are conducting a research study to compare the effectiveness of telehealth counseling plus electronic cigarettes VERSUS telehealth counseling plus nicotine replacement therapy (patches and ...Phase
Interventional
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A Phase II Randomized Double-Blind Placebo-Controlled Study of Ensifentrine in Subjects with Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to evaluate the effect and safety of the treatment Ensifentrine on the occurrence of pulmonary exacerbations and on patient-reported ...Phase
Interventional
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Autonomic Modulation in Takotsubo Syndrome
The purpose of this research study is to learn whether slow breathing is beneficial for patients with Takotsubo Syndrome. The RESPeRATE device will be used ...Phase
Interventional
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PBM-LEF Study: The Impact of Photobiomodulation (PBM) on Biomarkers of Radiation Lymphedema and Fibrosis in Head and Neck Cancer Patients: A Pilot Study
This study is testing if LED light therapy, called photobiomodulation (PBM), can help reduce tissue swelling and scarring in the neck area for head and ...
Phase
Interventional
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Randomized Phase II Clinical Trial of Olaparib + Pembrolizumab vs. Olaparib Alone as Maintenance Therapy in Metastatic Pancreatic Cancer Patients with Germline BRCA1 or BRCA2 Mutations
chemotherapy. The goals of the study are to check how safe and well-tolerated both treatments are, how long people stay without their cancer getting worse ...
Phase
Interventional
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VECTOR-HF IIb: a multi-center national open label single-arm prospective clinical study to evaluate the safety usability and performance of the V-LAP system
The purpose of this study is to evaluate whether the V-LAP™ system is safe, and to assess its performance in obtaining left atrial pressure measurement ...Phase
Interventional
