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Biomarker Stratified CaboZantinib (NSC#761968) and NivOlumab (NSC#748726 (BiCaZO) - A Phase II Study of Combining Cabozantinib and Nivolumab in Participants with Advanced Solid Tumors (IO Refractory Melanoma or HNSCC) Stratified by Tumor Biomarkers - an immunoMATCH Pilot Study
This is a pilot study to see whether biomarkers called Tumor Mutation Burden (TMB) and Gene Expression Profiling (GEP) can be used to study the ...
Phase
Interventional
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A Phase II Trial Evaluating Chemotherapy followed by Response-Based Reduced Radiation Therapy for Patients with Central Nervous System Germinomas
This is a phase II study, testing if lowering the dose of standard radiotherapy (RT) after standard chemotherapy medicines (Carboplatin & Etoposide) works well with fewer ...
Phase
Interventional
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Novel Targeting of the Microenvironment to Decrease Metastatic Recurrence of High-Risk TNBC: A Randomized Phase II Study of Tetrathiomolybdate (TM) Plus Capecitabine in Patients with Breast Cancer at High Risk of Recurrence
Scientific Rationale for the study design: Copper depletion is designed to be a complement to standard therapy to overcome resistance mechanisms hence it would be ...Phase
Interventional
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Comparison of High Dose vs. Standard Dose Influenza Vaccines in Lung Allograft Recipients
The purpose of this study is to investigate if receiving two doses of Fluzone High-Dose is better than receiving two doses of the standard dose ...Phase
Interventional
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A Phase 2 Double-blind Placebo-Controlled Study to Evaluate LY3537021 for the Treatment of Chemotherapy-Induced Nausea and Vomiting in Adult Participants With Malignant Disease
This is a Phase 2 study testing how safe and effective a medicine called LY3537021 is when added to standard anti-nausea treatment. LY3537021 is a ...
Phase
Interventional
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A Global Phase 2b Randomized Double-Blinded Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients with Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy FORTITUDE-HCM
The purpose of this study is to examine the effects of ninerafaxstat (an investigational drug) in people who are experiencing symptoms from their Non-Obstructive Hypertrophic ...Phase
Interventional
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An Open-label Multi-center Global Phase II Clinical Study to Evaluate the Efficacy and Safety of HLX43 (Anti-PD-L1 ADC) in Subjects with Advanced Non-small Cell Lung Cancer (NSCLC)
This is a Phase 2 study testing different doses of a medicine called HLX43 for patients with advanced non-small cell lung cancer (NSCLC). HLX43 is ...
Phase
Interventional
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A Phase 2 Randomized Double-blind Placebo-controlled Parallel Study Evaluating the Safety and Efficacy of LB-P8 in Patients with Primary Sclerosing Cholangitis (PSC)
This main purpose of this placebo-controlled study to assess the safety and efficacy of LB-P8 in adult patients with Primary Sclerosing Cholangitis (PSC). The study ...Phase
Interventional
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A Phase IIb Randomized Double-blind Placebo-controlled Parallel Multidose Study to Evaluate the Efficacy Safety and PK of AZD0292 in Participants With Bronchiectasis and Chronic Pseudomonas aeruginosa Colonization
The purpose of this research is to learn more about an experimental drug, called AZD0292, including how safe it is, how long it stays in ...Phase
Interventional
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A Phase 2 Open-Label Study to Evaluate the Safety and Efficacy of Intravesical Instillation of TARA-002 in Adults with High-Grade Non-Muscle Invasive Bladder Cancer
Study TARA-002-101-Ph2 is an open-label Phase 2 study to investigate the safety and efficacy of TARA-002 administered intravesically in adults 18 years of age or ...Phase
Interventional
