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A Phase 3 Multinational Randomized Placebo-controlled Study of ARRY-371797 in Patients with Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation
This multinational Phase 3 study will evaluate the efficacy, safety and PK following treatment with ARRY-371797 compared with placebo (1:1 randomization) in at least ...Phase
Interventional
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CHARM: Glibenclamide for Large Hemispheric Infarction Analyzing mRS and Mortality. A Multicenter Double-Blind Placebo-Controlled Randomized Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 for Severe Cerebral Ed
This is a Phase 3 study, which means that BIIB093 (study drug) has already been investigated in previous clinical research studies with a small number ...Phase
Interventional
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Zenith p-Branch Pivotal Study
The purpose of this study is to assess the safety of the Zenith® p-Branch® and how well it works in combination with Atrium iCAST™ covered ...Phase
Interventional
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A phase III randomized double blind parallel group placebo controlled international multicentre study to assess efficacy and safety of Cx601 adult allogeneic expanded adipose-derived stem cells (eASC) for the treatment of complex perianal fistula(
The purpose of this study is to confirm (1) how well the investigational drug, Cx601, works at a single dose of 120 million cells compared ...Phase
Interventional
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HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease.
This study is testing an investigational drug called inclisiran which lowers bad (LDL) cholesterol in the blood. Study doctors hope that giving this injection every ...Phase
Interventional
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Sleep for Stroke Management And Recovery Trial (Sleep SMART)
This research is being done to figure out whether treatment for sleep apnea, in people who have had a stroke or TIA, improves recovery from ...Phase
Interventional
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AALL1731: A Phase 3 Trial Investigating Blinatumomab (IND# 117467 NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy)
While outcomes in SR B-ALL have improved significantly, this population still accounts for approximately half of the overall burden of relapse among children with ALL ...Phase
Interventional
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A Phase 3 Randomized Double-blind Study to Evaluate Perioperative Pembrolizumab (MK-3475) + Neoadjuvant Chemotherapy versus Perioperative Placebo + Neoadjuvant Chemotherapy in Cisplatin-eligible Participants with Muscle-invasive Bladder Cancer (KEYNOTE-866)
This is a research study involving the drug pembrolizumab. The purpose of this study is to: o See if the study drug, pembrolizumab, in combination ...Phase
Interventional
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A Phase 3 Multicenter Open-Label Extension Trial of Oral RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis
The purpose of this study is to see whether ozanimod (RPC1063), (also referred to as the ‘study drug’), is safe and how well it works ...Phase
Interventional
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Randomized Controlled Pivotal Trial of Autologous Bone Marrow Mononuclear Cells Using the CardiAMP Cell Therapy system in Patients with Post Myocardial Infarction Heart Failure (CardiAMP Heart Failure Trial)
The purpose of this study is to evaluate the CardiAMP cell therapy system as a treatment for patients with heart failure as a result of ...Phase
Interventional
