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Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
The primary purpose of the study is to determine if accelerated BEP ((Bleomycin, Etoposide, and cisPlatin) is effective and tolerable for patients with advanced germ ...Phase
Interventional
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A Randomized Placebo-Controlled Double-Blind Study of Adjuvant Cemiplimab Versus Placebo after Surgery and Radiation Therapy in Patients with High Risk Cutaneous Squamous Cell Carcinoma (CSCC); R2810-ONC-1788
The main purpose of this study is to determine if the study drug, Cemiplimab, will prevent cutaneous squamous cell cancer from returning after surgery and ...Phase
Interventional
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ACNS1833: A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)
ACNS1833 is a prospective randomized phase 3 study comparing selumetinib to CV in previously untreated LGG not associated with neurofibromatosis or BRAFV600E. This non-inferiority study ...Phase
Interventional
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A Phase 3 Global Double-Blind Randomized Placebo-Controlled Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Transthyretin-Mediated Amyloid Cardiomyopathy
The purpose of this study is to evaluate the safety of ION-682884 and determine if it can help people with cardiomyopathy.ION-682884 is an investigational ...Phase
Interventional
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A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727 IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1(NF1)
The purpose of the study is to find out the safety and efficacy of the drug selumetinib in treating patients with low-grade glioma. We want ...Phase
Interventional
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A Multicenter Open-Label Extension Study to Assess the Long-Term Safety Tolerability and Efficacy of Bimekizumab in the Treatment of Subjects with Active Psoriatic Arthritis
The purpose of this study is to help us understand how safe, effective and tolerable an investigational new drug called bimekizumab (bye-me-key-zoo-mab) is for a ...Phase
Interventional
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Recombinant tPA by Endovascular Administration for the treatment of Submassive pulmonary embolism using pharmaco-mechanical Catheter directed thrombolysis for the reduction of thrombus burden (RESCUE study)
This is an experimental research study of a device manufactured by Thrombolex, Inc., (the study sponsor). The study device is for the treatment of a ...Phase
Interventional
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STATINS USE IN INRACEREBRAL HEMORRHAGE PATIENTS (SATURN)
This research is being done to find out if it is better to continue or discontinue statin drugs in people who had a brain hemorrhage ...Phase
Interventional
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Anticoagulation for Stroke Prevention and Recovery after ICH (ASPIRE)
Survivors of intracerebral hemorrhage (ICH) who have atrial fibrillation (AF) are at high risk for subsequent ischemic stroke. An “ischemic” stroke is an injury to ...Phase
Interventional
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Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients with Previously Untreated Metastatic Colorectal Cancer (SOLARIS)
The purpose of the study is to determine the efficacy and safety of how well vitamin D3 given with standard chemotherapy and bevacizumab works in ...Phase
Interventional
