Displaying 103 (all) recruiting clinical trials.
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A Randomized Double-Blind Placebo-Controlled Phase 3 Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients with Severe Hypertriglyceridemia
The purpose of this study is to determine the safety, tolerability, and efficacy of the study drug, olezarsen. Apolipoprotein C-III (apoC-III) is a protein found ...Phase
Interventional
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A Phase III Randomized Double-blind Placebo-controlled Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes Carrying the Genetic HLA DR3-DQ2 Haplotype
The purpose of this study is to test the safety and effectiveness of an investigational drug called Diamyd®. Diamyd® is considered “investigational” in this research ...Phase
Interventional
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Multicenter Adaptive Randomized Controlled Trial Platform To Evaluate Safety and Efficacy of Strategies and Treatments for Hospitalized Patients with Respiratory Infections(STRIVE)
We are studying an investigational drug for treatment of people in the hospital with COVID-19. This drug is investigational because it can only be used ...Phase
Interventional
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Gossamer - A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH)
The purpose of this study is to compare the effects of seralutinib to placebo (an inactive substance that looks like seralutinib and is given the ...Phase
Interventional
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A randomized double-blind double-dummy parallel-group study comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis followed by extended treatment with open-label remibrutinib
The purpose of this research study is to compare remibrutinib and teriflunomide safety and efficacy in patients with relapsing forms of Multiple Sclerosis (RMS).Phase
Interventional
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LTI-401 An Open-Label Prospective Multicenter Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in Pulmonary Hypertension ASCENT
The purpose of this research study is to evaluate the long-term safety and tolerability of LIQ861 in patients with pulmonary hypertension (elevated pressure in your ...Phase
Interventional
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CLOU064C12301 - A randomized double-blind double-dummy parallel-group study comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis followed by extended treatment with open-label remibrutinib
The main purpose of the study is to find out if patients treated with remibrutinib may experience fewer multiple sclerosis (MS) relapses (also called clinical ...Phase
Interventional
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A Phase 3 Randomized Study of Adjuvant Cretostimogene Grenadenorepvec versus Observation for the Treatment of Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR-NMIBC) Following Transurethral Resection of Bladder Tumor (TURBT)
This is a study that looks at how well a treatment called cretostimogene works after a procedure called TURBT for patients with intermediate-risk non-muscle invasive ...
Phase
Interventional
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A Phase 3 Randomized Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-0616 in Reducing Major Adverse Cardiovascular Events in Participants at High Cardiovascular Risk
The purpose of this research study is to test an experimental drug called MK-0616 in adults who are at high risk for serious illness, death ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults with Elevated Lipoprotein(a) who have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event ACCLAIM-Lp(a)
The purpose of this study is to investigate the effect of lepodisiran on the reduction of major adverse cardiovascular events (MACE) in adults with elevated ...Phase
Interventional
