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SELECT-SLE: A Phase 3 Program to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Moderately to Severely Active SLE
The purpose of this research study is to assess the safety and efficacy of upadacitinib compared with placebo (fake drug) for the treatment of signs ...Phase
Interventional
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A Prospective Multicenter Randomized Two-Arm Single-blind Superiority Trial to Evaluate the Safety and Efficacy of the MagicTouch Sirolimus-Coated Balloon in the Treatment of Coronary Drug-Eluting Stent In-Stent Restenosis (MAGICAL ISR)
The treatment for narrowed or blocked arteries often involves stents, which are inserted into heart blood vessels to alleviate blockages. Drug-eluting stents (DES) release medication ...Phase
Interventional
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WA43966: A Phase III Multicenter Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of RO7434656 An Antisense Inhibitor of Complement Factor B in Patients with Primary IgA Nephropathy at High Risk of Progression
The purpose of this study is to compare the safety and effects of RO7434656 versus placebo in participants with IgAN. In this study, you will ...Phase
Interventional
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A randomized double-blind placebo controlled 2-arm multicenter phase 3 study to assess the efficacy and safety of ianalumab in patients with active Sj gren s syndrome (NEPTUNUS-1)
The aim of this study is to find out how well treatment with ianalumab works in people with active Sjögren’s syndrome.Phase
Interventional
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A Phase 3 Randomized Double-blind Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults with Active Sj gren s Syndrome (POETYK-SjS-1)
This is the first time deucravacitinib is being studied in people with Sjogren’s Syndrome. By doing this study, researchers hope to learn more about ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Multicenter Study to Evaluate the Efficacy Safety and Tolerability of Psilocybin in Adults with Major Depressive Disorder
The purpose of this research study is to see if the investigational drug, psilocybin, can help people with major depressive disorder (MDD). This clinical trial ...Phase
Interventional
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A Randomized Double-Blind Placebo-Controlled Phase 3 Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients with Severe Hypertriglyceridemia
The purpose of this study is to determine the safety, tolerability, and efficacy of the study drug, olezarsen. Apolipoprotein C-III (apoC-III) is a protein found ...Phase
Interventional
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A Phase III Randomized Double-blind Placebo-controlled Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes Carrying the Genetic HLA DR3-DQ2 Haplotype
The purpose of this study is to test the safety and effectiveness of an investigational drug called Diamyd®. Diamyd® is considered “investigational” in this research ...Phase
Interventional
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Multicenter Adaptive Randomized Controlled Trial Platform To Evaluate Safety and Efficacy of Strategies and Treatments for Hospitalized Patients with Respiratory Infections(STRIVE)
We are studying an investigational drug for treatment of people in the hospital with COVID-19. This drug is investigational because it can only be used ...Phase
Interventional
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Gossamer - A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH)
The purpose of this study is to compare the effects of seralutinib to placebo (an inactive substance that looks like seralutinib and is given the ...Phase
Interventional
