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Phase 3 Study of ALXN1850 versus Placebo in Adolescent and Adult Participants with Hypophosphatasia (HPP) who have not previously been treated with Asfotase Alfa
The purpose of this study is to determine if the study medication is safe and effective in the treatment of hypophosphatasia (HPP) for adults and ...Phase
Interventional
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A Study to Evaluate PF-06823859 in People With Active Idiopathic Inflammatory Myopathies (Including Dermatomyositis or Polymyositis)
The purpose of this research study is to learn about the effects of the study drug PF-06823859 for treating dermatomyositis (DM) or polymyositis (PM).Phase
Interventional
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The IRIS trial: A clinical trial for people living with active lupus nephritis (LN)
IRIS is looking to see if a new FDA-approved therapy called SAPHNELO® may be effective in treating people with active LN. SAPHNELO® is the brand ...Phase
Interventional
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A Phase 3 Randomized Open-Label Study to Compare the Efficacy and Safety of Anitocabtagene Autoleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Multiple Myeloma
This study is testing the efficacy and potential side effects of a novel CAR-T cell treatment called anitocabtagene autoleucel (anito-cel). It is being compared to ...
Phase
Interventional
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s23-00723: A Phase 3 Randomized Active-controlled Open-label Multicenter Study to Compare the Efficacy and Safety of MK-2870 Monotherapy Versus Treatment of Physician s Choice in Participants With Endometrial Cancer Who Have Received Prior Platinum-based Chemotherapy and Immunotherapy (MK-2870-005/ENGOT-en23/GOG-3095)
This study is studying two treatments: MK-2870 versus chemotherapy (doxorubicin or paclitaxel) to see which is more effective for patients with endometrial cancer. It involves ...
Phase
Interventional
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Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (PREDICT-RT*)
In this study, patients are divided into two groups based on their Decipher score, which helps determine their risk level. High-risk patients, with a Decipher ...
Phase
Interventional
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Double-Blind Placebo-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults with Severe Hypertriglyceridemia (SHASTA-3 Study)
The purpose of this research study is to look at how safe and effective ARO-APOC3 is at lowering triglycerides in people with severe hypertriglyceridemia. Hypertriglyceridemia ...Phase
Interventional
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A randomized phase 3 open-label study to evaluate SGN-B6A compared with docetaxel in adult subjects with previously treated non-small cell lung cancer
This is a study for adult patients who had lung cancer (specifically NSCLC or non-small cell lung cancer) before and are going to try two ...
Phase
Interventional
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Randomized Clinical Evaluation of the AccuCinch Ventricular Restoration System in Patients who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF)
The purpose of this research study is to assess the safety and effectiveness of the AccuCinch Ventricular Restoration System and compare it to standardized heart ...Phase
Interventional
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RASolute 302: A Phase 3 Multicenter Open-label Randomized Study of RMC-6236 versus Investigator s Choice of Standard of Care Therapy in Patients with Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
This study is being done to find out if the treatment RMC-6236 can help patients with advanced pancreatic cancer live longer or keep their cancer ...
Phase
Interventional
