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ACNS1931: A Phase 3 Study of Selumetinib (NSC# 748727 IND# 77782) or Selumetinib in Combination with Vinblastine for non-NF1 non-TSC Patients with Recurrent or Progressive Low-Grade Gliomas (LGGs) Lacking BRAFV600E or IDH1 Mutations
The purpose of the study is to determine and investigate the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine ...
Phase
Interventional
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A Phase 3 Study to Evaluate the Efficacy and Safety of ARO-APOC3 in Adults with Familial Chylomicronemia Syndrome
The purpose of this study is to test two different dose levels of ARO-APOC3 administered 4 times, 3 months apart in people with Familial Chylomicronemia ...Phase
Interventional
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AGCT1532 - Phase 3 Accelerated BEP Trial: A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours
The purpose of this study is to investigate the accelerated BEP in improving the safety and efficacy for patients with intermediate and poor-risk metastatic germ ...
Phase
Interventional
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A randomized double-blind phase III study comparing NIS793 in combination with gemcitabine and nab-paclitaxel versus placebo combined with gemcitabine and nab-paclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)
The purpose of the study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in ...Phase
Interventional
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A Randomized Controlled Pragmatic Phase 3b/4 Study of Baricitinib in Patients with Rheumatoid Arthritis
The purpose of this research study is to help determine the safety of a drug called baricitinib. Baricitinib is a type of medicine called a ...Phase
Interventional
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A Phase III Randomized Double-Blind Placebo-Controlled Multicenter Study to Evaluate the Efficacy Safety Pharmacokinetics and Pharmacodynamics of Satralizumab as Monotherapy or in Addition to Baseline Therapy in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
The purpose of this study is to compare the effects, good or bad, of satralizumab with placebo alone or in combination with current treatment (baseline ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Fixed-Dose Multicenter Study to Examine the Efficacy and Safety of ZX008 in Subjects with CDKL5 Deficiency Disorder Followed by an Open-Label Extension
The purpose of this study is to learn more about patients with CDKL5 Deficiency Disorder and the potential efficacy of investigational study drug, ZX008. “Investigational ...Phase
Interventional
