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A two-part randomized placebo controlled double blind multicenter Phase 3 study to evaluate the efficacy and safety of linerixibat for the treatment of cholestatic pruritus in participants with primary biliary cholangitis (PBC) (GLISTEN)
The purpose of this study is to further test an investigational drug called linerixibat (also referred to as GSK2330672) for the treatment of cholestatic pruritus ...Phase
Non-Interventional
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The Effect of Semaglutide in Non-Cirrhotic Non-Alcoholic Steatohepatitis
We are doing this study to see if the medicine called semaglutide can help patients with NASH get better and reduce their risk of future ...Phase
Interventional
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A Randomized Open-Label Multicenter Phase 3 Trial of Domvanalimab Zimberelimab and Chemotherapy Versus Nivolumab and Chemotherapy in Participants with Previously-Untreated Locally Advanced Unresectable or Metastatic Gastric Gastroesophageal Junction and Esophageal Adenocarcinoma
This study is designed for patients who have Untreated Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma
This is a phase 3 ...
Phase
Interventional
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A randomized parallel-group double-blind placebo-controlled multicenter Phase III trial to investigate the efficacy and safety of secukinumab 300 mg administered subcutaneously versus placebo both in combination with a glucocorticoid taper regimen i
The purpose of this research study is to demonstrate if secukinumab 300 mg and secukinumab 150 mg administered as an injection under the skin is ...Phase
Interventional
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PHASE III RANDOMIZED OPEN-LABEL MULTICENTER STUDY EVALUATING EFFICACY AND SAFETY OF MOSUNETUZUMAB IN COMBINATION WITH LENALIDOMIDE IN COMPARISON TO RITUXIMAB IN COMBINATION WITH LENALIDOMIDE IN PATIENTS WITH FOLLICULAR LYMPHOMA AFTER AT LEAST ONE LINE OF SYSTEMIC THERAPY
The purpose of the study is to evaluate the efficacy and safety of mosunetuzumab in combination with lenalidomide (M +Len) compared with rituximab in combination ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults with Obesity
The purpose of this study is to determine if tirzepatide is better than a placebo in reducing obesity-related disease and death in adults living with ...Phase
Interventional
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A Multicenter Randomized Double-Blind Placebo-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of BIIB059 in Adult Participants With Active Systemic Lupus Erythematosus Receiving Background Non-Biologic Lupus Standard of Care
The purpose of the study is to investigate if the investigational study drug BIIB059 can reduce disease activity and inflammation in people with active systemic ...Phase
Interventional
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Randomized Double-blind Placebo-Controlled Multicenter Phase 3 Study to Evaluate the Safety Tolerability and Efficacy of XEN1101 as Adjunctive Therapy in Focal-Onset Seizures
In this research a study drug named XEN1101 is being tested for the treatment of seizures. XEN1101 is a study drug because its safety, effectiveness ...Phase
Interventional
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Roadster 3
The purpose of this research study is intended to evaluate real world usage of the ENROUTE® Transcarotid Stent when used with the ENROUTE® Transcarotid Neuroprotection ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants with Active Systemic Lupus Erythematosus (POETYK-SLE-2)
This study is a double-blinded 52-week clinical trial to evaluate the efficacy and safety of deucravacitinib in adult participants with active Systemic Lupus Erythematosus (SLE ...Phase
Interventional
