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PARAGLIDE-HF
The purpose of this study is to assess the effect of sacubitril/valsartan vs. valsartan on changes in NT-proBNP and outcomes, safety, and tolerability in ...Phase
Interventional
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A Phase 3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients with Autosomal Dominant Polycystic Kidney Disease
The study will examine if bardoxolone methyl, a drug being developed by Reata Pharmaceuticals, can improve autosomal dominant polycystic kidney disease (ADPKD), with its disease-modifying ...Phase
Non-Interventional
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A Randomized Controlled Trial to compare the effectiveness of Fecal Microbiota Transplantation (FMT) in combination with Bezlotoxumab compared to FMT and placebo for the prevention of CDI recurrence in patients with Inflammatory Bowel Disease and Recurrent Clostridium difficile Infection
This study will find out if fecal microbiota transplantation (also known as FMT) paired with Bezlotoxumab compared to FMT and placebo is a better treatment ...Phase
Interventional
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Optimizing Retention Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy (RDD)
This multicenter study seeks to better evaluate treatment strategies for the management of opioid use disorder – it aims to improve treatment outcomes for both patients ...Phase
Interventional
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ASSURE: An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC)
The purpose of this research study is to evaluate the long-term safety and tolerability of seladelpar in treating PBC patients. Primary Biliary cholangitis (PBC) is ...Phase
Interventional
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CAreful Ventilation In COVID 19-induced ARDS - The CAVIARDS 19 Trial
ARDS is a severe form of lung injury which makes breathing very difficult and limits the ability of the respiratory system to provide oxygen to ...Phase
Interventional
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A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy
The purpose of the study is to determine the efficacy of MRTX849 in combination with cetuximab versus chemotherapy (FOLFIRI or mFOLFOX6) administered in the second-line ...Phase
Interventional
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The DIAbetes TELEmedicine MEDiterranean Diet Study (DIATELEMED)
The purpose of this research study is to compare 3 different dietary management approaches for achieving blood sugar control for people with early-stage type 2 ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Study of Pembrolizumab versus Placebo in Combination with Adjuvant Chemotherapy with or without Radiotherapy for the Treatment of Newly Diagnosed High-Risk Endometrial Carcinoma After Surgery with Curative Intent (MK3475 B21/ENGOT-en11/GOG-3053)
The purpose of the study is to determine and compare pembrolizumab and adjuvant chemotherapy with placebo and adjuvant chemotherapy, with or without radiotherapy, in relation ...Phase
Interventional
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Effects of MRI Acceleration: Comparison with the Current NYU Standard
The purpose of this research study is to evaluate faster magnetic resonance imaging (MRI). The study will test whether accelerated MRI examinations with reduced scan ...Phase
Interventional
