Displaying 125 (all) recruiting clinical trials.
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WUH: A randomized double-blind placebo-controlled study of diazoxide choline controlled-relealese tablet (DCCR) in patients with prader-Willi Syndrome.
The purpose of this research is to evaluate if diazoxide choline controlled-release (DCCR) tablet has an effect on hyperphagia (increased appetite) and other aspects of ...Phase
Interventional
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MK-3475 (SCH 9000475) as neoadjuvant and adjuvant therapy in Stage III-IVA resectable
The purpose of this research study is to: • Test the safety of the study drug, pembrolizumab (MK-3475) • Test how your cancer responds to one of ...Phase
Interventional
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A Phase 3 22-week Multi-center Randomized Withdrawal Study of TD-9855 in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure
This is a Phase 3, multi-center, randomized withdrawal study to evaluate the sustained benefit in efficacy and safety of TD-9855 in subjects with primary autonomic ...Phase
Interventional
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Combined Phase 3 Double-blind Randomized Placebo-Controlled Studies Evaluating the Efficacy and Safety of Filgotinib in the Induction and Maintenance of Remission in Subjects with Moderately to Severely Active Crohn s Disease
The purpose of this study is to see if filgotinib is effective and safe in treating people with moderate to severe Crohn’s disease. The ...Phase
Interventional
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A Phase 3 Multinational Randomized Placebo-controlled Study of ARRY-371797 in Patients with Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation
This multinational Phase 3 study will evaluate the efficacy, safety and PK following treatment with ARRY-371797 compared with placebo (1:1 randomization) in at least ...Phase
Interventional
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CHARM: Glibenclamide for Large Hemispheric Infarction Analyzing mRS and Mortality. A Multicenter Double-Blind Placebo-Controlled Randomized Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 for Severe Cerebral Ed
This is a Phase 3 study, which means that BIIB093 (study drug) has already been investigated in previous clinical research studies with a small number ...Phase
Interventional
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To evaluate the efficacy safety and tolerability of 6-week extended interval dosing of Natalizumab (BG00002) switching from treatment with 4-Week Natalizumab standard interval dosing (SID) in relation to continued SID treatment
The main purpose of this study is to evaluate the efficacy, safety, and tolerability of 6-week extended interval dosing of Natalizumab (BG00002) switching from treatment ...Phase
Interventional
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A Phase 3 Matrix Design Partially Double-Blind Randomized Study of the Efficacy and Safety of 50 mg Lonafarnib/100 mg Ritonavir BID with and without 180 mcg PEG IFN-alfa-2a for 48 Weeks Compared with PEG IFN-alfa-2a Monotherapy and Placebo Treatment in Patients Chronically Infected with Hepatitis Delta Virus Being Maintained on Anti-HBV Nucleos(t)ide Therapy (D-LIVR)
Although there is no preventative vaccine or approved treatment for HDV, researchers are studying new treatments for HDV. This research study is designed to learn ...Phase
Interventional
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Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure: a randomized trial (TAVR UNLOAD)
The purpose of the trial is to evaluate the use of a device to treat patients with Heart Failure (HF) who have moderate aortic stenosis ...Phase
Interventional
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Zenith p-Branch Pivotal Study
The purpose of this study is to assess the safety of the Zenith® p-Branch® and how well it works in combination with Atrium iCAST™ covered ...Phase
Interventional
