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WA43966: A Phase III Multicenter Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of RO7434656 An Antisense Inhibitor of Complement Factor B in Patients with Primary IgA Nephropathy at High Risk of Progression
The purpose of this study is to compare the safety and effects of RO7434656 versus placebo in participants with IgAN. In this study, you will ...Phase
Interventional
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A Phase 3 Randomized Double-blind Placebo-controlled Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults with Active Sj gren s Syndrome (POETYK-SjS-1)
This is the first time deucravacitinib is being studied in people with Sjogren’s Syndrome. By doing this study, researchers hope to learn more about ...Phase
Interventional
Accepts Healthy Volunteer
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A Phase III Randomized Double-blind Placebo-controlled Multicenter Trial to Evaluate the Efficacy and Safety of Diamyd to Preserve Endogenous Beta Cell Function in Adolescents and Adults with Recently Diagnosed Type 1 Diabetes Carrying the Genetic HLA DR3-DQ2 Haplotype
The purpose of this study is to test the safety and effectiveness of an investigational drug called Diamyd®. Diamyd® is considered “investigational” in this research ...Phase
Interventional
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LTI-401 An Open-Label Prospective Multicenter Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in Pulmonary Hypertension ASCENT
The purpose of this research study is to evaluate the long-term safety and tolerability of LIQ861 in patients with pulmonary hypertension (elevated pressure in your ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Program to Evaluate the Efficacy and Safety of Tulisokibart in Participants with Moderately to Severely Active Crohn s Disease
This trial is testing an experimental drug tulisokibart (MK-7240) in people with moderately to severely active Crohn’s disease (CD). This trial will compare tulisokibart ...Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Program to Evaluate the Efficacy and Safety of MK-7240 in Participants with Moderately to Severely Active Ulcerative Colitis
This trial is testing MK-7240 in people with moderate to severely active ulcerative colitis (UC). This trial will compare MK-7240 to placebo. A placebo looks ...Phase
Interventional
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NRG-BR009: A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1 ER Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score = 25 (OFSET)
This study wants to see if giving extra chemotherapy (adjuvant chemotherapy (ACT) to ovarian function suppression plus endocrine therapy) helps premenopausal women with early-stage breast ...
Phase
Interventional
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A Study to Evaluate PF-06823859 in People With Active Idiopathic Inflammatory Myopathies (Including Dermatomyositis or Polymyositis)
The purpose of this research study is to learn about the effects of the study drug PF-06823859 for treating dermatomyositis (DM) or polymyositis (PM).Phase
Interventional
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The IRIS trial: A clinical trial for people living with active lupus nephritis (LN)
IRIS is looking to see if a new FDA-approved therapy called SAPHNELO® may be effective in treating people with active LN. SAPHNELO® is the brand ...Phase
Interventional
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Randomized Clinical Evaluation of the AccuCinch Ventricular Restoration System in Patients who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF)
The purpose of this research study is to assess the safety and effectiveness of the AccuCinch Ventricular Restoration System and compare it to standardized heart ...Phase
Interventional
