Displaying 127 (all) recruiting clinical trials.
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A Randomized Double-blind Placebo-controlled Parallel-group Multicenter Study to Evaluate the Efficacy and Safety of SOtaglifloziN in symptomATic obstructive And non-obstructive Hypertrophic CardioMyopathy
The purpose of this study is to determine the effectiveness in treating symptoms and functional limitations in patients with symptomatic hypertrophic cardiomyopathy (HCM) treated with ...Phase
Interventional
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A Multi-Center Randomized Double-Blind Placebo- and Active-Controlled Phase 3 Study to Evaluate the Efficacy and Safety of Zasocitinib (TAK-279) in Subjects With Active Psoriatic Arthritis Who Are Na ve to Biologic Disease-Modifying Antirheumatic Drugs
The purpose of this study is to assess the safety of Zasocitinib and how well patients with psoriatic arthritis respond to it. The study also ...Phase
Interventional
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Phase 3 Study of Dotinurad vs Allopurinol in Participants with Gout
The purpose of this research study is to find out whether a new medicine called dotinurad can lower uric acid levels and prevent gout attacks ...Phase
Interventional
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A Phase 3 Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of Plozasiran in Adults with Hypertriglyceridemia (SHASTA-10 Study)
This study will be conducted in adults with HTG and SHTG. Enrolled subjects will be counseled to remain on the specified low-fat diet throughout the ...Phase
Interventional
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A Phase 3 Multicenter Randomized Double-Masked Vehicle-Controlled Study to Demonstrate Efficacy and Safety of DFL24498 Eye Drop Solution in Adult Participants with Atopic Keratoconjunctivitis (AKC)
Researchers at NYU Langone Health’s Ophthalmology Department are doing a study to test how safe and effective an investigational eye drop (DFL24498 0.08 ...Phase
Interventional
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RANDOMIZED OPEN-LABEL STUDY OF THE BRIA-IMT REGIMEN AND CHECK POINT INHIBITOR VS PHYSICIAN'S CHOICE IN ADVANCED METASTATIC BREAST CANCER (BRIA-ABC)
This study is testing a new treatment called Bria-IMT (an experimental immunotherapy treatment) for patients with advanced breast cancer that has spread (metastatic) or come ...
Phase
Interventional
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A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants with Persistent Obesity or Overweight Treated with a Weekly Incretin with and without Type 2 Diabetes (ENLIGHTEN-6)
The purpose of this study is to learn more about eloralintide, a possible new treatment for obesity and for those that are overweight as an ...Phase
Interventional
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A Phase III randomized multi-site open-label trial of BNT323/DB-1303 versus investigator s choice of chemotherapy in previously treated patients with HER2-expressing recurrent endometrial cancer (GOG 3105)
This is a Phase III study that is testing how well BNT323 works compared to a single chemotherapy drug chosen by the doctor. BNT323 is ...
Phase
Interventional
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A Phase 3 Randomized Open-label Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care After Second-line Platinum-based Doublet Chemotherapy in Participants With Platinum-sensitive Recurrent Ovarian Cancer (TroFuse-022/ENGOT-ov84/GOG-3103)
This is a Phase 3 randomized (split into groups by chance) study designed to compare how well and how safely sacituzumab tirumotecan, with or without ...
Phase
Interventional
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A Phase 3 Randomized Open-label Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab With or Without Bevacizumab Compared With Standard of Care as Firstline Maintenance Treatment for Participants With Persistent Recurrent or Newly Diagnosed Metastatic Cervical Cancer With PD-L1 CPS Greater Than or Equal to 1
This is a Phase 3 study testing a new experimental drug called sacituzumab tirumotecan (sac-TMT, also known as MK-2870) to see if it can help ...
Phase
Interventional
