Displaying 51 (all) recruiting clinical trials.
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A PHASE 1/2 STUDY OF REGN5093-M114 (METXMET ANTIBODY-DRUG CONJUGATE) IN PATIENTS WITH MET OVEREXPRESSING ADVANCED CANCER
The purpose of the study is to determine and investigate the safety, tolerability and efficacy of REGN5093-M114, a METxMET ADC, in patients with MET-overexpressing advanced ...Phase
Interventional
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10301 - A Phase I and Randomized Phase II Trial of Radium-223 dichloride M3814 & Avelumab in Advanced Metastatic Castrate-Resistant Prostate Cancer (mCRPC)
The purpose of the study is to determine the best dose of M3814 when given together with radium-223 dichloride or with radium-223 dichloride and avelumab ...Phase
Interventional
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A Phase 1/2 Study of M3814 (peposertib) in Combination with Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma ( s21-00991)
The purpose of the study is to determine the side effects and best dose of M3814. We want to see how well the drug M3814 ...Phase
Interventional
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A Phase I/II Randomized Double-Blind Placebo-Controlled Trial of Cannabidiol for chronic radiculopathic pain syndromes maintained on chronic opioid therapy
The purpose of this research study is to see how safe and effective Cannabidiol (CBD) is for the treatment of chronic non-cancer spinal radiculopathic pain ...Phase
Interventional
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A Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Metastatic Colorectal Cancers
The purpose of the study is to characterize the safety and efficacy profile of a combination of anti-cancer therapies in participants with previously treated metastatic ...Phase
Interventional
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A Phase 1/2 Dose Escalation And Dose Expansion Study Of BA3021 Alone And In Combination With Nivolumab In Patients With Advanced Solid Tumors
The purpose of the study is to determine and evaluate the safety, tolerability, immunogenicity, and antitumor activity of BA3021 alone and in combination with nivolumab ...Phase
Interventional
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A Phase 1/2 Study of EG-70 as an Intravesical Administration to Patients with BCG-Unresponsive NMIBC
The purpose of the study is to evaluate the safety and efficacy of intravesical administration of EG-70 and its effect on bladder tumors in patients ...Phase
Interventional
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A Phase 1/2 Study of the Highly Selective EGFR Inhibitor BLU-701 in Patients with EGFR-Mutant Non-Small Cell Lung Cancer
The purpose of the study is to determine the overall safety of the study drug BLU-701, as assessed by the type, frequency, severity, timing, and ...
Phase
Interventional
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A Phase 1/2a Multi-Center Open-Label Study to Evaluate the Safety Tolerability Pharmacokinetics and Preliminary Evidence of Antitumor Activity of JAB-3312 in combination with pembrolizumab or binimetinib in Adult Patients with Advanced Solid Tumors
The purpose of the study is to determine and demonstrate the safety and tolerability of JAB-3312 in combination with anti-PD-1 or MEKi in patients with ...Phase
Interventional
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A Phase 1/2 Open-label Study Investigating the Safety Tolerability and Efficacy of ASP7517 in subjects with Relapsed/Refractory Acute Myeloid Leukemia (AML) and Relapsed/Refractory Higher Risk Myelodysplastic Syndrome (MDS)
The purpose of the study is to evaluate the safety and tolerability of intravenous infusion of ASP7517 (human embryonic kidney cell transfected with encoding target ...Phase
Interventional
